One can obtain 'chemically pure' elements, but 'isotopically pure' or enriched is much more difficult. One could use ultrahighspeed centrifuge technology, mass spectrometry, or atomic-vapor laser isotopic separation or a more recent version of LIS, known as SILEX (
http://en.wikipedia.org/wiki/Silex_Process ).
http://www.sea-us.org.au/corpfilez/no2lasers.htmlLi, B, C, O, Si, Zn, Gd and U are elements 'enriched' to increase the proportion of a particular isotope well beyond the natural proportion, but they still have more than one isotope.
Here is more -
http://www.silex.com.au/s03_about_silex/s30_1_content.htmlhttp://www.silex.com.au/s11_technical/content.html